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Scientists studying the effects of the potentially game-changing gene-editing tool CRISPR/Cas9 have found it can cause unexpected genetic damage which could lead to dangerous changes in some cells. The findings, published in the journal Nature Biotechnology in 2018, have safety implications for gene therapies that are being developed using CRISPR/Cas9 – a type of molecular … Read more

Protein folding in the cell often relies on the help of chaperonins, naturally occurring cellular nanomachines that fold many critical cellular proteins in all human and animal cells. Knowledge of protein folding is important because proteins must assume the correct 3-D structure to function properly. Different classes of chaperones work together to form elaborate cooperative … Read more

Cell Squeeze® is a commercial technology designed to manipulate individual cells (ie. a patient’s own cells) through mild perturbation that leaves the cells viable after mechanoporation – or the insertion of a cargo directly into a cell’s cytosol. SQZ Biotech is the sole developer of this technology. One early application consists of a microchip that … Read more

Understanding the link between chromosomes and genes starts with indexing. When you type a query into an Internet search engine, a worldwide web search engine, you can get an answer back in less than a second because a company like Google has already indexed the entire readable Internet. Indexing is also at the core for … Read more