What Is Cell Squeeze Technology?

What Is Cell Squeeze Technology?

Cell Squeeze® is a commercial technology designed to manipulate individual cells through mild perturbation that leaves the cells viable after mechanoporation. SQZ Biotech is the developer of the technology. One early application consists of a microchip that gently forces antigen-presenting cells (APCs) to pass through a narrow channel in a microfluidic device. Pressure temporarily disrupts … Read more

How To Locate A Gene

How To Locate A Gene

Understanding the link between chromosomes and genes starts with indexing. When you type a query into an Internet search engine, a worldwide web search engine, you can get an answer back in less than a second because a company like Google has already indexed the entire readable Internet. Indexing is also at the core for … Read more

How Optogenetics Offers Pain Relief

How Optogenetics Offers Pain Relief

More than 50 million Americans suffer from chronic pain, and many are prescribed opioid medications as treatment. But the benefits of long-term opioid treatment for chronic pain are unclear, and patients risk developing drug tolerance (needing higher doses) and hyperalgesia (increased pain sensitivity). Use of these medications may also lead to dependence or even addiction. … Read more

How CRISPR-Cas9 Leads To Therapies

How CRISPR-Cas9 Leads To Therapies

Despite a new Nobel prize for the CRISPR discovery, there has been a lot of conversation surrounding CRISPR-Cas9 in these recent months as well as many sensational news stories. Some of these stories highlight the promise this technology holds, while others emphasize a word of caution. But what exactly does this technology do and how … Read more

Yogurt’s Role In The Early Development Of The CRISPR Gene Editing System

Yogurt’s Role In The Early Development Of The CRISPR Gene Editing System

Eugene Koonin’s dabbling with Streptococcus thermophilus eventually led him to discover CRISPR before CRISPR was a thing. An evolutionary biologist and senior investigator in the National Library of Medicine’s National Center for Biotechnology Information (NCBI), Koonin hypothesized in 2005 that “spacer DNA” in the clustered regularly interspaced short palindromic repeats (CRISPR) loci of bacteria and … Read more

In Conversation: Dr. Bradley Harding Discusses DNA-Computing

In Conversation: Dr. Bradley Harding Discusses DNA-Computing

Dr. Bradley Harding is a scientist specializing in DNA-based computing. His research, recently published in the prestigious journal Nano Letters, holds the potential to advance the field reusable biodevices controlled by logical operations. Dr. Harding’s research was co-supervised by the University of the Sunshine Coast’s Dr Joanne Macdonald and Dr Nina Pollak, assisted by collaborator … Read more

Recent Advances In CRISPR Technology Bring Precision Editing Closer To Reality In Human Cells

Recent Advances In CRISPR Technology Bring Precision Editing Closer To Reality In Human Cells

One problem with CRISPR technology to date has been unwanted off-target edits. Even the best CRISPR tool, SpCas9, can only bind to about one in 16 locations along DNA, leaving many genetic mutations out of reach. Now, researchers have designed a more precise and versatile genome editing system, named prime editing, that harnesses the power … Read more