The Link Between Evolution And Immunotherapy

The Link Between Evolution And Immunotherapy

According to Dr. Francis Collins, evolutionary studies – comparing the development of these systems across animals and organisms – are now leading to unexpected biological discoveries and promising possibilities for preventing and treating human disease. While there are many evolutionary questions to ask, Brenda Bass, a distinguished biochemist at University of Utah, Salt Lake City, … Read more

What Are Biological Pathways?

What Are Biological Pathways?

Many things must work together at many different levels – from organs to cells to genes – for your body to develop properly and stay healthy. From both inside and outside the body, cells are constantly receiving chemical cues prompted by such things as injury, infection, stress or even the presence or lack of food. … Read more

What Are Cell-Free Systems?

What Are Cell-Free Systems?

Living systems are not only complex, they are relentless in their demands to be kept alive, with all the attendant limitations and challenges for experimentation and measurement. So-called “cell-free systems” inhabit the space between chemistry and biology proper, obviating some of the requirements of living, cell-based systems and enabling biochemical processes and experimental interventions toxic, … Read more

Deciphering Genetic Variations: Bionano Genomics

Deciphering Genetic Variations: Bionano Genomics

Bionano Genomics is a life sciences instrumentation company in the genome analysis space. The company develops and markets the Saphyr system, a platform for ultra-sensitive and ultra-specific structural variation (SV) detection that enables researchers and clinicians to accelerate the search for new cancer diagnostics and therapeutic targets and to modernize the practice of cytogenetics. The … Read more

FDA: Artificial Intelligence/Machine Learning (AI/ML)-Based Software As A Medical Device (SaMD)

FDA: Artificial Intelligence/Machine Learning (AI/ML)-Based Software As A Medical Device (SaMD)

Human biology and new, more advanced computing is creating new territory for therapies that were not capable even five years ago. Artificial intelligence (AI) and machine learning (ML) technologies have the potential to transform health care by deriving new and important insights from the vast amount of health data. Medical device manufacturers are using these … Read more

What Is RNA Interference?

What Is RNA Interference?

The human genome is comprised of approximately 22,000 genes, each embodied as a region of deoxyribonucleic acid (DNA) that contains codes for the synthesis of certain proteins. DNA, which consists of building blocks known as “nucleotides,” occurs in the familiar “double helix” shape, with two strands coiled around the same axis. One end of a … Read more

Risks With CRISPR Gene Editing

Risks With CRISPR Gene Editing

Scientists studying the effects of the potentially game-changing gene-editing tool CRISPR/Cas9 have found it can cause unexpected genetic damage which could lead to dangerous changes in some cells. The findings, published in the journal Nature Biotechnology in 2018, have safety implications for gene therapies that are being developed using CRISPR/Cas9 – a type of molecular … Read more

Recent Advances In The Protein Folding Problem

Recent Advances In The Protein Folding Problem

Protein folding in the cell often relies on the help of chaperonins, naturally occurring cellular nanomachines that fold many critical cellular proteins in all human and animal cells. Knowledge of protein folding is important because proteins must assume the correct 3-D structure to function properly. Different classes of chaperones work together to form elaborate cooperative … Read more