How CAR T Cells Are Engineered To Treat Cancers

How CAR T Cells Are Engineered To Treat Cancers

For years, the foundations of cancer treatment were surgery, chemotherapy, and radiation therapy. Over the last two decades, targeted therapies like imatinib (Gleevec®)  and trastuzumab (Herceptin®) —drugs that target cancer cells by homing in on specific molecular changes seen primarily in those cells—have also cemented themselves as standard treatments for many cancers. But over the past several years, immunotherapy—therapies that enlist and … Read more

STEM Jobs: Fastest-Growing Occupations

STEM Jobs: Fastest-Growing Occupations

The number of STEM jobs — science, technology, engineering and mathematics — is in a secular growth storm, having sped past the number of non-STEM jobs by three times since 2000. Students pursuing STEM education will be positioned to benefit from the wave of innovations in synthetic biology. And experts say there might not be enough graduates in those fields to fill … Read more

IPO: Absci Corporation Aims For Proteins As Next-Generation Therapeutics

IPO: Absci Corporation Aims For Proteins As Next-Generation Therapeutics

Absci Corp describes itself as an AI-powered integrated drug creation platform. The company creates protein-based drugs (biologics) by unifying biologic drug discovery and cell line development into one process. This places Absci squarely under the umbrella of synthetic biology. The challenge in next-generation biologics is the linear steps needed to screen and select desired molecular … Read more

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How Immune Macrophages Communicate

How Immune Macrophages Communicate

Students of synthetic biology soon discover that living things are more adaptive and creative than most people ever imagined. According to Perry Marshall in his book, Evolution 2.0: Breaking the Deadlock Between Darwin and Design, “Darwinists underestimate nature and Creationists underestimate God.” Cells forming symbiotic relationships and communicating in complex ways suggests limitations to the … Read more

WARF Dive: Synthetic Ligands Capable of Strongly Inhibiting or Inducing Quorum Sensing in Bacteria

WARF Dive: Synthetic Ligands Capable of Strongly Inhibiting or Inducing Quorum Sensing in Bacteria

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a powerful new class of chemical probes that are capable of strongly inhibiting or inducing quorum sensing. Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules, including low … Read more

AbbVie, Biogen and Pfizer Create World’s Largest Browsable Resource Linking Rare Protein-Coding Genetic Variants

AbbVie, Biogen and Pfizer Create World’s Largest Browsable Resource Linking Rare Protein-Coding Genetic Variants

Today, access to the world’s largest browsable resource linking rare protein-coding genetic variants to human health and disease was launched through a genetic exome sequence analysis collaboration between AbbVie, Biogen Inc. and Pfizer. Managed by the Broad Institute of MIT and Harvard, the browser gives access to results from analyses of whole exome sequencing data … Read more

IPO: Caribou Biosciences Advances Cell Therapy With CRISPR

IPO: Caribou Biosciences Advances Cell Therapy With CRISPR

Caribou Biosciences is a clinical-stage biopharmaceutical company innovating in next-generation, genome-edited cell therapies. Its CRISPR hybrid RNA-DNA (chRDNA) guide technology has demonstrated superior specificity and high efficiency in preclinical studies, and, according to the company, has the potential to generate gene and cell therapies in oncology and in therapeutic areas beyond oncology, including immune cell … Read more

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Here’s A New Coalition Dedicated To Fostering American Synthetic Biology Manufacturing

Here’s A New Coalition Dedicated To Fostering American Synthetic Biology Manufacturing

In April, three leading synthetic biology companies announced the launch of the Synthetic Biology (SynBio) Coalition (www.synbioco.com) to promote investment and support for the American synthetic biology industry. Synthetic biology is a field of science that involves redesigning microorganisms for useful purposes.  It is already being leveraged across many industries, including pharmaceuticals and medical treatments, … Read more