Yogurt’s Role In The Early Development Of The CRISPR Gene Editing System

Yogurt’s Role In The Early Development Of The CRISPR Gene Editing System

Eugene Koonin’s dabbling with Streptococcus thermophilus eventually led him to discover CRISPR before CRISPR was a thing. An evolutionary biologist and senior investigator in the National Library of Medicine’s National Center for Biotechnology Information (NCBI), Koonin hypothesized in 2005 that “spacer DNA” in the clustered regularly interspaced short palindromic repeats (CRISPR) loci of bacteria and … Read more

In Conversation: Dr. Bradley Harding Discusses DNA-Computing

In Conversation: Dr. Bradley Harding Discusses DNA-Computing

Dr. Bradley Harding is a scientist specializing in DNA-based computing. His research, recently published in the prestigious journal Nano Letters, holds the potential to advance the field reusable biodevices controlled by logical operations. Dr. Harding’s research was co-supervised by the University of the Sunshine Coast’s Dr Joanne Macdonald and Dr Nina Pollak, assisted by collaborator … Read more

Recent Advances In CRISPR Technology Bring Precision Editing Closer To Reality In Human Cells

Recent Advances In CRISPR Technology Bring Precision Editing Closer To Reality In Human Cells

One problem with CRISPR technology to date has been unwanted off-target edits. Even the best CRISPR tool, SpCas9, can only bind to about one in 16 locations along DNA, leaving many genetic mutations out of reach. Now, researchers have designed a more precise and versatile genome editing system, named prime editing, that harnesses the power … Read more

In Conversation: Dr. Nina Pollak’s Vision For A Cleaner Environment Using Synthetic Biology

In Conversation: Dr. Nina Pollak’s Vision For A Cleaner Environment Using Synthetic Biology

I interviewed Dr Nina Pollak via Zoom to discuss her research interests and career aspirations. She is presently a CSIRO Synthetic Biology Future Science Fellow at the Molecular Engineering Group led by A/Prof Macdonald at the University of the Sunshine Coast in Australia. Originally from Austria, Dr. Pollak has completed a number of international research projects … Read more

The eMERGE Network Is A Biorepsitory That Combines EHR And Genomics

The eMERGE Network Is A Biorepsitory That Combines EHR And Genomics

The Electronic Medical Records and Genomics (eMERGE) Network develops, disseminates, and applies approaches to research that combine biorepositories with electronic medical record systems for genomic discovery and genomic medicine implementation research. eMERGE is a National Institutes of Health (NIH)-organized and funded consortium of U.S. medical research institutions. The Network brings together researchers with a wide … Read more

How The FDA Defines Real World Evidence

How The FDA Defines Real World Evidence

The Food and Drug Administration (FDA) uses real world data (RWD) and real world evidence (RWE) to monitor postmarket safety and adverse events – and also to make regulatory decisions. The 21st Century Cures Act, passed in 2016, places additional focus on the use of these types of data to support regulatory decision making, including … Read more