Synthetic Biology Features Prominently In Pershing Square Foundation’s Recent Funding Awards To Fight SARS-CoV-2 Virus

The Pershing Square Foundation recently announced that it has awarded $3 million to nineteen recipients at ten academic research institutions in furtherance of conducting research related to the SARS-CoV-2 virus.

As scientists across various disciplines around the world have risen to the challenge of combating SARS-CoV-2, The Pershing Square Foundation (the “Foundation”) worked with its network of cancer research scientists and physician-scientists involved in the Pershing Square Sohn Cancer Research Alliance (“PSSCRA”) to create a funding opportunity for SARS-CoV-2 research. The Foundation’s PSSCRA initiative annually awards a cancer research prize that provides funding and emboldens early-career investigators to pursue early-stage research projects.

“The Foundation remains committed to supporting cancer research and we are proud of the PSSCRA community that we have built over the last seven years,” said Foundation Trustee Bill Ackman. “Amid this global health crisis, we felt that we had an opportunity to quickly leverage the expertise of this exceptional scientific community to identify areas in which we could rapidly deploy funds to scientists researching SARS-CoV-2 in a way similar to our approach to funding cancer research.”

By tapping the PSSCRA community for this project, the Foundation sought to foster synergy among experts across cancer research, immunotherapy/immunology, genetics, and epigenetics to shed new light on SARS-CoV-2 research, expand basic scientific knowledge, and strengthen the arsenal for current and future health crises. Proposals were evaluated for innovation, scientific excellence, and application to the SARS-CoV-2 virus. This request for proposals built on the Foundation’s commitment to rigorous scientific research, support of risky and early-stage projects that could lead to innovation, and funding for fundamental, biological discoveries that might not otherwise receive support.

“There has never been a more important time to support scientific research and we are so thankful for our scientific community,” said Olivia Tournay Flatto, PhD, Co-Founder and Executive Director of the Pershing Square Sohn Cancer Research Alliance and President of The Pershing Square Foundation. “This community has been working tirelessly to break down the silos between institutions and build on the synergy across findings in cancer research and SARS-CoV-2. The Foundation is extremely appreciative of these scientists who are combining excellence and commitment towards understanding of human biology and disease. It is an honor to work with them.”

The grantees and research projects are (listed alphabetically by research institution):

  • Mikala Egeblad, PhD, Cold Spring Harbor Laboratory – “Targeting Neutrophil Extracellular Traps in COVID-19” @megeblad
  • David Tuveson, MD, PhD, and Tobias Janowitz, MD, PhD, Cold Spring Harbor Laboratory– “Famotidine as outpatient treatment for mildly to moderately symptomatic patients with COVID-19” @CSHL
  • Adolfo Ferrando, MD, PhD, Columbia University – “Novel antiviral PROTACs for the treatment of COVID-19, emerging viral pathogens and cancer
  • Carla Kim, PhD, Harvard University – “Organoid Modeling for COVID-19”
  • Nina Bhardwaj, MD, PhD, Icahn School of Medicine at Mt. Sinai – “Deconvolution of SARS-Cov-2-specific immune responses in COVID-19 patients for broadly effective vaccines” @MountSinaiNYC
  • Eirini Papapetrou, MD, PhD, Icahn School of Medicine at Mt. Sinai – “Genetic Determinants of COVID-19 Disease Severity
  • Benjamin Greenbaum, PhD, Matthew Hellmann, MD, and Jedd Wolchok, MD, PhD, Memorial Sloan Kettering Cancer Center – “Etiology and Immune Repertoire Evolution in SARS-CoV-2 in Patients Treated with Checkpoint Blockade Immunotherapies” @sloan_kettering
  • Christine Mayr, MD, PhD, Memorial Sloan Kettering Cancer Center – “A role for RNA as checkpoint for protein complex assembly”
  • Santosha Vardhana, MD, PhD and Omar Abdel-Wahab, MDMemorial Sloan Kettering Cancer Center – “Leveraging cancer-driven immune dysregulation to understand and enhance anti-COVID-19 immunity”
  • Dafna Bar-Sagi, PhD, New York University – “Determination of the Cellular Sources of IL-6 Release and Signaling in COVID-19”
  • Jef Boeke, PhD, New York University – “High-throughput, Automated RT-PCR Testing for Coronavirus and Beyond”
  • Liam Holt, PhD, New York University and Arvin Dar, PhD, Icahn School of Medicine at Mt. Sinai – “A Synthetic Viral-Like-Particle Vaccine against SARS-CoV-2”
  • Agnel Sfeir, PhD, New York University – “Investigating the interplay between SARS-Cov-2 and mitochondrial function”
  • Ali Brivanlou, PhD, The Rockefeller University, “Capitalizing on stem cell-derived synthetic human lungs on microchips to block SARS-CoV-2” see VIDEO
  • Daniel Mucida, PhD and Sohail Tavazoie, MD, PhD, The Rockefeller University – “Mucosal immunogenetics and an oral therapy for COVID-19
  • Howard Chang, MD, PhDStanford University, “Understanding Sex-biased Immunity to COVID-19”
  • John Blenis, PhD and Lewis Cantley,PhD, Weill Cornell Medicine – “Targeting cellular protein kinases as treatment for COVID-19”
  • Christopher Mason, PhDWeill Cornell Medicine – “TINY COVID: Rapid, Mobile, and Point-of-care Diagnostics for SARS-CoV-2 from Saliva
  • Silvia Rouskin, PhD, Whitehead Institute for Biomedical Research – “Discovery of SARS2 RNA structure-based therapeutic targets” @RouskinLab

As part of the selection process, The Pershing Square Foundation relied on the guidance of highly accomplished leaders in academia, industry, and public health.

Since 2013, the Pershing Square Sohn Cancer Research Alliance has awarded over $22 million to 39 talented scientists. With this funding, provided at the early stage of their promising careers, the recipients are contributing to the growth of New York City as a biomedical research hub. In addition to funding, the Alliance provides Prize winners with opportunities to present their work to scientific and business audiences, helping to bridge the gap between the academic and business communities. The winners of the 2020 Pershing Square Sohn Prize for Young Investigators in Cancer Research will be announced later this July.

About The Pershing Square Foundation
The Pershing Square Foundation (PSF) was established in 2006 to support exceptional leaders and innovative organizations that tackle important social issues and deliver scalable and sustainable impact across the globe. PSF has committed over $400 million in grants and social investments across a number of fields, including health and medicine, education, economic development and social justice. Since 2019, Bill Ackman and Neri Oxman have served as co-trustees of the Foundation. By investing in pioneering individuals, non-profits and mission driven companies who dare to re-imagine the possible, PSF has helped to bring about important breakthroughs — from cancer research and small-scale agriculture to criminal justice reform and educational opportunities for young people in communities around the world.

About The Pershing Square Sohn Cancer Research Alliance
The Pershing Square Sohn Cancer Research Alliance was formed in 2013 through a $25 million commitment by The Pershing Square Foundation, which partnered with The Sohn Conference Foundation. The Alliance is dedicated to playing a catalytic role in accelerating cures for cancer by supporting innovative cancer research and by facilitating collaborations between academia and industry. Annually, the Alliance awards the Pershing Square Sohn Prize to young New York based scientists who are engaged in cutting-edge cancer research.

Synthetic Biology Features Prominently In Pershing Square Foundation’s Recent Funding Awards To Fight SARS-CoV-2 Virus was last modified: July 9th, 2020 by Staff