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WARF Dive: Synthetic Ligands Capable of Strongly Inhibiting or Inducing Quorum Sensing in Bacteria

WARF Dive: Synthetic Ligands Capable of Strongly Inhibiting or Inducing Quorum Sensing in Bacteria

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a powerful new class of chemical probes that are capable of strongly inhibiting or inducing quorum sensing. Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules, including low … Read more

AbbVie, Biogen and Pfizer Create World’s Largest Browsable Resource Linking Rare Protein-Coding Genetic Variants

AbbVie, Biogen and Pfizer Create World’s Largest Browsable Resource Linking Rare Protein-Coding Genetic Variants

Today, access to the world’s largest browsable resource linking rare protein-coding genetic variants to human health and disease was launched through a genetic exome sequence analysis collaboration between AbbVie, Biogen Inc. and Pfizer. Managed by the Broad Institute of MIT and Harvard, the browser gives access to results from analyses of whole exome sequencing data … Read more

IPO: Caribou Biosciences Advances Cell Therapy With CRISPR

IPO: Caribou Biosciences Advances Cell Therapy With CRISPR

Caribou Biosciences is a clinical-stage biopharmaceutical company innovating in next-generation, genome-edited cell therapies. Its CRISPR hybrid RNA-DNA (chRDNA) guide technology has demonstrated superior specificity and high efficiency in preclinical studies, and, according to the company, has the potential to generate gene and cell therapies in oncology and in therapeutic areas beyond oncology, including immune cell … Read more

Categories IPO

Here’s A New Coalition Dedicated To Fostering American Synthetic Biology Manufacturing

Here’s A New Coalition Dedicated To Fostering American Synthetic Biology Manufacturing

In April, three leading synthetic biology companies announced the launch of the Synthetic Biology (SynBio) Coalition (www.synbioco.com) to promote investment and support for the American synthetic biology industry. Synthetic biology is a field of science that involves redesigning microorganisms for useful purposes.  It is already being leveraged across many industries, including pharmaceuticals and medical treatments, … Read more

Liquid Biopsy Company Grail Presents Multi-Cancer Early Detection Results

Liquid Biopsy Company Grail Presents Multi-Cancer Early Detection Results

In June, GRAIL, Inc., presented the first results from the interventional PATHFINDER study evaluating Galleri™, a multi-cancer early detection (MCED) blood test. The results, presented at the 2021 ASCO Annual Meeting, support Galleri’s performance in clinical settings. The company also announced today that Galleri is now available in the U.S. by prescription only.  “The interim … Read more

Simulations Guide Rapid Engineering Of New Functions In Mammalian Cells

Simulations Guide Rapid Engineering Of New Functions In Mammalian Cells

A change of instructions in a computer program directs the computer to execute a different command. Similarly, synthetic biologists are learning the rules for how to direct the activities of human cells.  “Cells are intricate machines that have evolved many interacting circuits—sets of genes that coordinate functions like migration, metabolism, and cell division,” explains David … Read more

Startup Dyno Therapeutics Applies AI To Gene Therapy

Startup Dyno Therapeutics Applies AI To Gene Therapy

Dyno Therapeutics applies artificial intelligence (AI) and quantitative in vivo experiments to gene therapy. The company’s proprietary CapsidMap™ platform discovers and systematically optimizes Adeno-Associated Virus (AAV) capsid vectors that is designed to outperform current approaches for in vivo gene delivery, thereby expanding the range of diseases treatable with gene therapies. In a paper published recently … Read more