Synthetic

WARF Dive: Synthetic Ligands Capable of Strongly Inhibiting or Inducing Quorum Sensing in Bacteria

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a powerful new class of chemical probes that are capable of strongly inhibiting or inducing quorum sensing.

Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules, including low molecular weight ligands like acyl-homoserine lactones (AHL), into the environment. When a certain number of signaling molecules accumulates and the population reaches a sufficient density, the bacteria change their behavior to work together for a common goal. For example, they may adapt to the nutrients that are currently available, defend against other microorganisms or protect themselves from toxic compounds.

View U.S. Patent No. 7,910,622 in PDF format

Agents that interfere with quorum sensing signals may reduce the virulence of certain types of pathogenic bacteria. When bacteria cannot work together to coordinate their attack, the likelihood of infection decreases. However, few synthetic modulators of quorum sensing are known.

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The Invention

UW-Madison researchers have developed non-native ligands that can block or imitate quorum sensing signals.  The ligands include N-phenylacetanoyl-L-homoserine lactones that are capable of inhibiting or strongly inducing quorum sensing in the bacterial symbiont Vibrio fischeri.  The invention also includes methods of using the synthetic ligands to treat infections or modulate biofilm formation. Applications

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For current licensing status, please contact Rafael Diaz at rdiaz@warf.org or 608-960-9847

WARF Dive: Synthetic Ligands Capable of Strongly Inhibiting or Inducing Quorum Sensing in Bacteria was last modified: July 13th, 2021 by Staff