What Is Cell Squeeze Technology?

What Is Cell Squeeze Technology?

Cell Squeeze® is a commercial technology designed to manipulate individual cells through mild perturbation that leaves the cells viable after mechanoporation. SQZ Biotech is the developer of the technology. One early application consists of a microchip that gently forces antigen-presenting cells (APCs) to pass through a narrow channel in a microfluidic device. Pressure temporarily disrupts … Read more

China’s Military Joins Forces With Biotech Companies To Propel COVID Vaccine Efforts

China’s Military Joins Forces With Biotech Companies To Propel COVID Vaccine Efforts

Xi Jinping has called upon the Chinese People’s Liberation Army (PLA) to become a world-class military (世界一流军队) by mid-century. Chinese military modernization has been directed towards learning from and targeting the U.S. military, which is seen as a powerful adversary (强敌). In 2015, China’s President Xi Jinping made science and innovation a key element of … Read more

How To Locate A Gene

How To Locate A Gene

Understanding the link between chromosomes and genes starts with indexing. When you type a query into an Internet search engine, a worldwide web search engine, you can get an answer back in less than a second because a company like Google has already indexed the entire readable Internet. Indexing is also at the core for … Read more

NIH’s 4DN Nucleome Program Targets DNA

NIH’s 4DN Nucleome Program Targets DNA

The goal of the National Insitute of Health’s (NIH) Common Fund’s 4D Nucleome (4DN) program is to study the three-dimensional organization of the nucleus in space and time (the 4th dimension). The nucleus of a cell contains DNA, the genetic “blueprint” that encodes all of the genes a living organism uses to produce proteins needed … Read more

How Optogenetics Offers Pain Relief

How Optogenetics Offers Pain Relief

More than 50 million Americans suffer from chronic pain, and many are prescribed opioid medications as treatment. But the benefits of long-term opioid treatment for chronic pain are unclear, and patients risk developing drug tolerance (needing higher doses) and hyperalgesia (increased pain sensitivity). Use of these medications may also lead to dependence or even addiction. … Read more

How CRISPR-Cas9 Leads To Therapies

How CRISPR-Cas9 Leads To Therapies

Despite a new Nobel prize for the CRISPR discovery, there has been a lot of conversation surrounding CRISPR-Cas9 in these recent months as well as many sensational news stories. Some of these stories highlight the promise this technology holds, while others emphasize a word of caution. But what exactly does this technology do and how … Read more

What Illumina Ventures’ Portfolio Says About The Science And Business Models Of The Future Care Delivery System

What Illumina Ventures’ Portfolio Says About The Science And Business Models Of The Future Care Delivery System

A look inside a leading venture capital firm’s portfolio is like a lens for understanding the current state of the future of healthcare. Illumina Ventures’ is an independently-managed, healthcare-focused venture firm in a strategic partnership with Illumina, Inc. The portfolio illustrates as much about business models as it does about the science behind synthetic biology. … Read more

This Chinese Biotech Is Developing A Immune-privileged Cell And Organ Platform

This Chinese Biotech Is Developing A Immune-privileged Cell And Organ Platform

Hangzhou Qihan Biotechnology Co., Ltd. is innovating in transplantable cells, tissues, and organs to solve the massive organ shortage crisis. The company targets the scientific challenge of specific cell therapy by developing a multiplexable high-throughout gene-editing platform. The platform’s key feature is to reduce the immunogenicity of human stem cells, thus limiting their ability to … Read more